Jan Baptist van Helmont, born in Brussels in 1580, was a chemist, physiologist, and physician whose work helped shape the future of modern science.
Discovering Belgium reader Mansur Sultani recently suggested that I write about the remarkable life and work of Jan Baptist van Helmont. So here is my profile of this 17th-century thinker who transformed the fields of chemistry and medicine. His work resonates with scientific principles still in use today.
Introduction: The man who bridged alchemy and chemistry
A philosopher, physician, chemist, and alchemist, van Helmont is perhaps best known for his pioneering experiments that contributed to the birth of chemistry as a distinct scientific discipline. Although deeply influenced by the mystical and spiritual leanings of alchemy, van Helmont used experimentation and observation in ways that anticipated the scientific method. His insights into gases, physiology, and medicine had lasting effects on future generations of scientists, including Robert Boyle and Antoine Lavoisier.
Early life: A journey from wealth to wonder
Jan Baptist van Helmont was born on 12 January, 1580 in Brussels (part of the Spanish Netherlands at the time) into a wealthy and influential Flemish family. He was the youngest of five children of Maria van Stassaert and Christiaen van Helmont, a public prosecutor and Brussels council member.
His early education reflected the humanist ideals of the time, with a classical curriculum focusing on Latin, philosophy, and theology. Although his family encouraged him to pursue a career in law, van Helmont had little interest in this path.

After brief studies in law at the University of Leuven, he shifted his focus to medicine and obtained a medical degree in 1599. His dissatisfaction with the traditional, Galenic understanding of medicine, which revolved around the balance of bodily humors, led him on a quest for a more empirical and holistic understanding of the natural world. This desire would shape the rest of his life, as van Helmont set out to redefine what science and medicine could achieve.
A research lab in Neder-over-Heembeek
He practiced at Antwerp at the time of the great plague in 1605, after which he wrote a book titled De Peste (The Plague), which was reviewed by Newton in 1667. In 1609 he married Margaret van Ranst, who was of a wealthy noble family. Van Helmont and Margaret lived in Vilvoorde and had six or seven children. The inheritance of his wife (and from his father who died in 1580) enabled him to retire early from his medical practice and occupy himself with research for the rest of his life.
He had a laboratory built in Neder-over-Heembeek, close to the Church of Saints Peter and Paul. Unfortunately, the house he lived in no longer exists. However, a nearby street is named in his memory: La Venelle de l’Alchimiste (Alchemist’s Alley).
A radical thinker: Early influences and the draw of alchemy
Alchemy, a discipline blending spiritual and material exploration, was an early influence on van Helmont’s intellectual life. He was drawn to the Hermetic tradition, which saw the natural world as a source of hidden, mystical truths. However, van Helmont was no mere mystic. He believed that the path to unlocking nature’s secrets lay in rigorous experimentation and careful observation.
This combination of spiritual belief and experimental practice set him apart from many of his contemporaries. Van Helmont saw alchemy not simply as a means of transmuting base metals into gold, but as a way to understand the deeper workings of matter and life itself. His writings often blended theological reflection with scientific inquiry, a reflection of the deeply religious context in which he worked.
The birth of modern chemistry: van Helmont’s revolutionary ideas
One of van Helmont’s most significant contributions was his exploration of gases, which he referred to as “gas” (a term he coined, from the Greek word “chaos”). This was revolutionary, as gases were largely misunderstood at the time. His famous experiment involving the burning of charcoal showed that a substance was released during combustion, which he called “gas sylvestre,” or what we now recognize as carbon dioxide.
In another key experiment, van Helmont sought to disprove the idea of spontaneous generation and the old theory that all matter derived from the four elements – earth, water, air, and fire. He planted a willow tree in a pot containing a fixed amount of soil, carefully measuring the water he added. After five years, the tree had gained a significant amount of mass, yet the soil had barely decreased in volume. From this, van Helmont concluded that the growth of the tree came from water, not soil, laying the groundwork for future investigations into plant physiology and the role of photosynthesis.
Although he began as a follower of Paracelsus, van Helmont rejected many of his theories and refused to accept the Paracelsian first principles (sulphur, salt, and mercury) as pre-existent in matter, believing instead that sulphur, salt and mercury were products of reactions that involved heat.
Medicine and physiology: A pioneer in health sciences
Van Helmont was also a physician, and his contributions to medicine were significant. In an age when humoral theory (the idea that the body was governed by four fluids: blood, yellow bile, black bile, and phlegm) still dominated medical thought, van Helmont introduced a new way of thinking about illness and health.

He rejected the humoral theory and believed that diseases were caused by specific external agents, which was a radical departure from the prevailing ideas of the time. He was an early proponent of “iatrochemistry,” a field that sought to explain physiological processes and diseases in terms of chemical reactions within the body.
In 1609, van Helmont used chemical methods to study bodily products such as urine and blood. He studied the human body and its functions, and applied his findings as a way of understanding and curing the body. Van Helmont experimented with treatments that we now consider part of early pharmaceutical science, using chemicals such as mercury, sulfur, and various salts to treat patients. His work laid the foundation for the field of biochemistry and introduced concepts that would later evolve into the germ theory of disease.
A theological scientist: Balancing faith and experimentation
For van Helmont, the pursuit of scientific knowledge was deeply intertwined with his religious beliefs. He viewed nature as a divine creation and believed that through understanding the natural world, one could draw closer to understanding God. However, this blending of science and spirituality led to conflict with established authorities, particularly the Catholic Church.
At that time, Pope Urban VIII was the reigning pope. His reign was marked by a mixture of political, scientific, and theological challenges, and he is perhaps best known for his involvement in the trial of Galileo Galilei.

During this period, the Catholic Church was still closely monitoring scientific ideas that conflicted with traditional theological doctrine, especially if those ideas seemed to challenge church teachings. Van Helmont’s unorthodox medical and theological views caught the attention of Pope Urban VIII. In 1625, van Helmont was imprisoned by the Inquisition for publishing heretical views. Thankfully, van Helmont was eventually released and continued his scientific and medical work afterwards.
Despite these conflicts, van Helmont maintained his belief in a harmonious relationship between faith and reason. His works often reflected a desire to reconcile the mystical and empirical aspects of knowledge.
Legacy: The bridge between alchemy and science
Jan Baptist van Helmont died on 30 December 1644 at the age of 64. His legacy is that of a thinker who lived at the cusp of two intellectual worlds – alchemy and modern science. His work laid the groundwork for future chemists, including Robert Boyle, who is often credited with founding modern chemistry, and Antoine Lavoisier, who later refined the study of gases.
His son Franciscus Mercurius van Helmont (1614-1698) was an alchemist and writer. He is best known for his publication in the 1640s of his father’s pioneer works on chemistry, which link the origins of the science to the study of alchemy.

Although van Helmont’s theories were not always correct – he still believed in the existence of certain mystical forces – his empirical approach to understanding the natural world was ahead of its time. His work on gases, plant growth, and the chemical causes of disease paved the way for future scientific discoveries. The word “gas,” which he introduced, remains a lasting testament to his contributions.
Thanks Mansur for suggesting Jan Baptist van Helmont as the next in my series of Famous Belgians. If anyone else has a famous or just a remarkable Belgian you would like to see profiled here, just drop me a line and I will be happy to do the necessary research.
I created Discovering Belgium in 2011 to share the country’s hidden stories, fascinating places, and remarkable people. Through articles, photography, and audio walks, I share discoveries that reveal Belgium beyond the obvious. Hope you enjoy this site.
I was thinking as I was reading this that he probably put himself at risk with these radical theories. What a good thing he survived the Inquisition and was able to continue his amazing work.
Yes, it’s remarkable how religion has frequently tried to shut down science, always without success.
It’s amazing to see how van Helmont’s work laid such crucial foundations for both chemistry and medicine as we know them today. His balanced approach—bridging alchemy and empirical science—is truly inspiring and shows how the roots of modern science often emerged from unexpected places. I especially enjoyed reading about his insights into gases and plant physiology; his experiments must have been revolutionary at the time! Thank you for bringing attention to such an important figure in scientific history. Kudos to Mansur for the suggestion!
Thanks for your insightful comment Anna. Yes it’s easy to forget how revolutionary and innovative these early scientists were.
Hi Denzil,
We organize from 9 until 11 July in Antwerp a conference on the Philosophy of chemistry with Van Helmont as the central theme.
You can find more information on the conference website:
https://www.uantwerpen.be/en/conferences/28th-conference-of-the-international-society-for-the-philosophy-of-chemistry/
I hope to see you there!
Best regards,
Filip
Great initiative!